Ketone Supplementation May Address Bipolar Disorders

Dominic D’Agostino
2 min readMar 25, 2022

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Dominic D’Agostino is a University of South Florida professor and ketone research scientist who focuses on ketone ester technologies. Other focus areas include ketone supplementation and how ketone technologies boost muscle function. Dom D’Agostino also understands ketosis and psychiatric conditions, such as schizophrenia and bipolar disorder.

Bipolar disorder can be inherited and impacts people of all ages. This makes early diagnosis essential, even though symptoms may be challenging to identify. Traditional bipolar disorder treatments center on mood-stabilizing drugs that level out mood swings and assist in controlling manic symptoms.

Recent studies focus on complex metabolic pathways that appear to underpin psychiatric disease pathologies. Changes in metabolic function can significantly impact mental health, suggesting metabolic-based therapeutic interventions as a promising pathway for bipolar disorder.

While bipolar disorder treatments involving a ketogenic diet have not been extensively studied, reports reveal that ketone esters or ketone salts can deliver fast, sustained metabolic changes that stabilize brain energy metabolism and help to balanace neurotransmitters levels in the brain. Reducing neuron-inflammatory processes and enhancing mitochondrial function may work therapeutically to address central nervous system disorders such as bipolar disorder. Online reports also suggest that sustained nutritional ketosis is linked to mood stabilization, elevated energy, and mental clarity. Nutritional ketosis achieved through diet or supplementation is rapidly becoming a lifestyle approach to enhance cognitive function and work productivity. For more information on this topic, including research and science-based products visit: KetoNutrition.org

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Dominic D’Agostino
Dominic D’Agostino

Written by Dominic D’Agostino

Dr. Dominic D’Agostino has focused his work on the advancement and testing of treatments to help patients with cancer and degenerative muscle disorders.

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